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斑馬魚技術
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序號

名稱

       申請號

                     申請日

       1

一種利用斑馬魚篩選線粒體靶向化合物的方法

ZL 201010296696.9

2010.09.29

2

在整體斑馬魚上進行酶聯免疫吸附檢測的方法及應用

ZL 201010547814.9

2010.11.17

3

建立斑馬魚血栓模型的方法

ZL 201110126427.2

2011.05.17

4

斑馬魚P-糖蛋白抑制劑篩選模型的建立方法及其應用

ZL 201110231726.2

2011.08.12

5

斑馬魚多發性硬化癥模型的建立方法及其應用

ZL 201210016072.6

2012.01.18

6

一種斑馬魚細菌感染模型的構建方法及其應用

ZL 201210377599.1

2012.09.27

7

一種斑馬魚類過敏檢測模型的建立及其應用

ZL 201310262123.8

2013.06.27

8

一種斑馬魚體內ROS檢測模型的建立方法及其應用

ZL 201310398791.3

2013.09.05

9

一種能抗血管生成的化合物及其用途

ZL 201210562409.3

2012.12.18

10

左旋沙丁胺醇在制備抗血管生成類藥物中的應用

ZL 201310008036.X

2013.01.09

11

舒洛地爾在制備抗血管生成類藥物中的應用

ZL 201310020569.X

2013.01.18

12

一種抗PM2.5咀嚼片及其制備方法

ZL 201610216744.6

2016.04.06

13

用斑馬魚鰾損傷炎癥模型評價肺損傷治療劑與誘導劑的方法

ZL 201610956504.X

2016.11.03

14

一種用斑馬魚評價心肌損傷誘導劑毒性與治療劑功效的方法

ZL 201610969159.3

2016.11.03

15

天然抗癲癇活性化合物及其在藥物制劑中的用途(合作)

ZL 201410487432.X

2014.09.22

 

序號

論文/文章名稱

作者

發表刊物

發表年份

1

Aroclor1254 對斑馬魚胚胎發育、肝臟組織結構及其卵黃蛋白原基因的影響

徐娟,吳南翔,陳瓊姜,宋揚,陳汝家

環境與職業醫學

20119

2

Human cardiotoxic drugs delivered by soaking
and microinjection induce cardiovascular
toxicity in zebrafish

Jun-Jing Zhu, Yi-Qiao Xu, Jian-Hui He, Hang-Ping Yu, Chang-Jiang Huang,
Ji-Min Gao, Qiao-Xiang Dong, Yao-Xian Xuan and Chun-Qi Li

Journal of Applied Toxicology

201210

3

斑馬魚模型在藥物毒性與安全性評價中的應用

陳汝家,朱俊靖,周盛梅,辛艷飛,

宣堯仙, 李春啟

毒理學雜志

20126

4

斑馬魚高血脂模型在山青之片質量控制中的應用研究

郭殿武,周娟,唐禮可,吳耀東,彭忠華,

陳汝家,張勇,李春啟

中國藥品標準

2013

5

Aequorivita viscosa sp. nov., isolated from an
intertidal zone, and emended descriptions of
Aequorivita antarctica and Aequorivita
capsosiphonis

Jin-Jin Liu,Xin-Qi Zhang,Jie Pan,Cong Sun,Yong Zhang,Chun-Qi Li, Xu-Fen Zhu

and Min Wu

International Journal of Systematic and Evolutionary Microbiology (2013), 63, 31923196

2013

6

A zebrafish phenotypic assay for assessing drug-induced hepatotoxicity

Jian-Hui He, Sheng-Ya GuoFeng Zhu, Jun-Jing Zhu,Yun-Xiang Chen, Chang-Jiang Huang,Ji-Min Gao, Qiao-Xiang Dong, Yao-Xian Xuan and Chun-Qi Li

Journal of Pharmacological and Toxicological Methods

2013

7

Mutations in POFUT1, Encoding
Protein O-fucosyltransferase 1, Cause
Generalized Dowling-Degos Disease

Ming Li, Ruhong Cheng, Jianying Liang Heng Yan, Hui Zhang, Lijia Yang, Chengrang Li,Qingqing Jiao, Zhiyong Lu,Jianhui He, Jin Ji,Zhu Shen,

Chunqi Li, Fei Hao, Hong Yu

and Zhirong Yao

The American Journal of Human Genetics

20136

8

幾種植物原花青素及其片段化產物
的抗 ROS 活性評價

李美娟,勞喬聰,姜永新,俞航萍,

姜力, 李春啟,張加研,趙平

西 部 林 業 科 學

20142

9

Zebrafish models for assessing developmental and reproductive toxicity

Jian-Hui He,Ji-Min Gao, Chang-Jiang Huang, and Chun-Qi Li

Neurotoxicology and Teratology

2014

10

Tween-80 and Impurity Induce Anaphylactoid Reaction in Zebrafish

Rui Yang, Qiao-Cong Lao, Hang-Ping Yu, Yong Zhang, Hong-Cui Liu,
Lin Luan, Hui-Min Sun and Chun-Qi Li

Journal of Applied Toxicology

201410

11

Secretion of intestinal goblet cells: A novel excretion pathway
of nanoparticles

Baoquan Zhao, Lan Sun,  Wuxu Zhang,  Yuxia Wang,Junjing Zhu, Xiaoyu Zhu, Liuzhong Yang, Chunqi Li,Zhenzhong Zhang, Yingge Zhang

Nanomedicine: Nanotechnology, Biology, and Medicine
10 (2014) 839849

2014

12

Human prokinetic drugs promote gastrointestinal
motility in zebrafish

J ZHOU,S-Y. GUO, Y. ZHANG& C-Q. LI

Neurogastroenterology & Motility the Official Journal of the European Gastrointestinal Motility Society

2014

13

Developmental Toxicity of Diclofenac
and Elucidation of Gene Regulation in
zebrafish (Danio rerio)

Jia-Bin Chen, Hong-Wen Gao, Ya-Lei Zhang,Yong Zhang, Xue-Fei Zhou, Chun-Qi Li& Hai-Ping Gao

Scentific Reports

20148

14

Rapid analysis of hypolipidemic drugs in a live zebrafish assay

Juan Zhou, Yi-Qiao Xu, Sheng-Ya Guo, Chun-Qi Li

Journal of Pharmacological and Toxicological Methods 72 (2015) 4752

201412

15

Bioactive C21 Steroidal Glycosides from the Roots of Cynanchum
otophyllum That Suppress the Seizure-like Locomotor Activity of
Zebrafish Caused by Pentylenetetrazole

Jin-Long Li,Juan Zhou, 

Zhen-Hua Chen, Sheng-Ya Guo,

Chun-Qi Li, and Wei-Min Zhao

Journal of Natural Products

201412

16

Lignans and aromatic glycosides from Piper wallichii and their
antithrombotic activities

Yan-Ni Shi, Yi-Ming Sh, Lian Yang, Xing-Cong Li, Jin-Hua Zhao,Yan Qu,
Hong-Tao Zhu, Dong Wang, Rong-Rong Cheng, Chong-Ren Yang, Min Xu,
Ying-Jun Zhang

Journal of Ethnopharmacology

2014

17

Toxicity induced by Basic Violet 14, Direct Red
28 and Acid Red 26 in zebrafish larvae

Bing Shen,Hong-Cui Liu, Wen-Bin Oud, Grant Eilersf, Sheng-Mei Zhoug,
Fan-Guo Meng, Chun-Qi Li and Yong-Quan Li

Journal of Applied Toxicology

201412

18

Assessment of immunotoxicity of dibutyl phthalate using live
zebrafish embryos

Hai Xu, Xing Dong, Zhen Zhang, Ming Yang, Xiangyang Wu, Hongcui Liu,
Qiaocong LaoChunqi Li

Fish & Shellfish Immunology 45 (2015) 286e292

2015

19

Low-dose exposure of silica nanoparticles induces
cardiac dysfunction via neutrophil-mediated
inflammation and cardiac contraction in zebrafish
embryos

Junchao Duan, Yang Yu, Yang Li, Yanbo Li, Hongcui Liu, Li Jing, Man Yang, Ji
Wang, Chunqi Li & Zhiwei Sun

Taylor Francis

201511

20

基于斑馬魚模型進行馬兜鈴酸心血管毒性的評價

陳云祥,張城達,張麗麗,李磊,辛艷飛,

張立將,劉洪翠,黃燕烽,李春啟,宣堯仙

中華中醫藥學刊

20152

21

苯肼誘發建立斑馬魚血栓模型的方法

張 勇, 朱曉宇, 郭勝亞, 李春啟

實驗動物與比較醫學

2015

22

A VEGFR1 antagonistic peptide inhibits tumor growth
and metastasis through VEGFR1-PI3K-AKT signaling
pathway inhibitio

Zheng Zhou, Chuanke Zhao, Lixin Wang, Xiaodan Cao, Jian Li, Ruijing Huang, 

Qiaocong Lao, Hangping Yu, Yanna Li, Haiyan Du, Like Qu, Chengchao Shou


American Journal of Cancer Research

2015

23

6-O-Caffeoylarbutin inhibits melanogenesis in
zebrafish

Min Xu, Qiao-Cong Lao, Ping Zhao, 

Xiao-Yu Zhu, Hong-Tao Zhu, Xu-Lu Luo,
Chong-Ren Yang, Jian-Hui He, Chun-Qi Li & Ying-Jun Zhang

Natural Product Research
Formerly Natural Product Letters

201612

24

In Vivo Cardiotoxicity Induced by Sodium Aescinate
in Zebrafish Larvae

Jinfeng Liang, Wangdong Jin , Hongwen Li,Hongcui Liu, Yanfeng Huang,
Xiaowen Shan, Chunqi Li, Letian Shan , and Thomas Efferth

MOLECULES

20161

25

Development of a Zebrafish Model for Rapid Drug
Screening against Alzheimers Disease

Wenhai Huang, Chuansheng Li, Zhengrong Shen, Xiaoyu Zhu, Bo Xia and Chunqi Li

Journal of Pharmacy and Pharmacology

20164

26

斑馬魚神經元損傷模型在養血清腦顆粒質量控制中的應用分析

李曉穩,佟玲, 李東翔,孫國祥,朱桃桃,

李春啟

中國實驗方劑學雜志

2016

27

神香蘇合丸防治心血管疾病的實驗研究

朱曉宇,劉洪翠,俞航萍,郭勝亞,勞喬聰,李春啟

浙江理工大學學報

2016

28

A Zebrafish Thrombosis Model for Assessing Antithrombotic Drugs

Xiao-Yu Zhu, Sheng-Ya Guo,Bo Xia, Ru-Shun Song,Qiao-Cong Lao, Yao-Xian Xuan,and Chun-Qi Li

Zebrafish

2016

29

斑馬魚在中藥毒性靶器官研究中的進展

張勇  郭勝亞  鄧中平  李春啟

中國新藥雜志

2016

30

Closantel Suppresses Angiogenesis and Cancer
Growth in Zebrafish Models

Xiao-Yu Zhu, Bo Xia,Hong-Cui Liu, Yi-Qiao Xu,Chang-Jiang Huang,Ji-Min Gao, Qiao-Xiang Dong,and Chun-Qi Li

Assay & Drug Development Technologies

2016

31

Toxicity comparison of different active fractions extracted from
Radix Sophorae tonkinensis in zebrafish

Hong-cui LIU, Xiao-yu ZHU, Jiang-hua CHEN, Sheng-ya GUO, Chun-Qi LI, Zhong-ping DENG

Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)

201610

32

斑馬魚模型在藥物研發早期腎臟毒性中的應用研究

梁錦鋒,朱勇,張洪瑤,勞喬聰,馬敏康,

李春啟

中國比較醫學雜志

2016

33

小金膠囊對斑馬魚移植瘤的抗腫瘤作用

黃志軍,蘭小紅,趙剛,徐懿喬,吳木琴,

張勇, 李春啟

中成藥

2016

34

Acute hepatotoxicity induced by quetiapine fumarate in larval zebrafish

jinfeng liang,wangdong jin, haibin wei, hongwen li, fei jia ,jing qian,hongcui liu, yanfeng huang, chunqi li,lizhou and thomas efferth

Acute hepatotoxicity induced by quetiapine fumarate in larval zebrafish

2016

35

Manipulating the air-filled zebrafish swim bladder as a
neutrophilic inflammation model for acute lung injury

Yuefei Zhang, Hongcui Liu, Junlin Yao, Yanfeng Huang, Shenlu Qin, Zheng Sun, Yingchun Xu, Shu Wan, Hongqiang Cheng,
Chunqi Li, Xue Zhang and Yuehai Ke

Cell Death and Disease

2016

36

Investigation of hemostatic effect of Spleeninvigorating, Qi-replenishing and Bloodarresting Formula on simvastatin-induced
zebrafish hemorrhage model

Yuting Chu, Ling Zhang, Xiaoyu Zhu, Yayue Zhang,Bo Xia, Li Hou, Rushun Song, Tiantian Li, Chunqi Li,Qing Dong, Xinyi Chen

Journal of Traditional Chinese Medical Sciences

2016

37

斑馬魚模型評價5種中藥肝臟毒性

郭勝亞,朱曉宇,廖文瀚,李春啟

實驗動物科學

2016

38

以斑馬魚模型評價6種藥物的神經毒性

蘭小紅,朱曉宇,張勇,徐雷,李春啟

實驗動物科學

2016

39

以斑馬魚為模型評價酒石酸長春瑞濱注射用乳劑與水針劑的毒性

張洪瑤,賈 飛,錢 璟,勞喬聰,劉洪翠,

李春啟,陶巧鳳,郭殿武

中國新藥雜志

2016

40

冬蟲夏草促進PM2_5超細顆粒物排出的作用和機制探討

勞喬聰,孫嵐,張英鴿,蔡宏偉,肖瑛,

李靜,江曉梅,李春啟

食品科技

2017

41

藥物處理對失眠癥斑馬魚睡眠的影響以及相關作用機制

何東方,張麗軍,劉梅顏

中國循證心血管醫學雜志

20173

42

Comprehensive understanding of PM2.5 on gene and microRNA
expression patterns in zebrafish (Danio rerio) model

Junchao Duan, Yang Yu, Yang Li, Li Jing , Man Yang, Ji Wang, Yanbo Li, Xianqing Zhou,Mark R. Miller, Zhiwei Sun

Science of the Total Environment 586 (2017) 666674

2017

43

Multi-organ toxicity induced by ?ne particulate matter PM2.5

Junchao Duan, Hejing Hu, Yannan Zhang , Lin Feng, Yanfeng Sh,
Mark R. Miller, Zhiwei Sun

Chemosphere

2017

44

Component-based biocompatibility and safety
evaluation of polysorbate 80?

Huimin Sun,Rui Yang, Jue Wang, Xia Yang, Jiasheng Tu, Langui Xie,
Chunqi Li, Qiaocong Lao and Chunmeng Sun

RSC Adv.

2017

45

如意珍寶丸對斑馬魚神經損傷的保護及促再生作用研究

朱曉宇,王紅月,李懷平,王海蘋,蘭小紅,宋如順 ,李春啟

藥物評價研究

2017

46

斑馬魚模型評價如意珍寶丸抗炎鎮痛作用研究

杜婷婷,王海蘋,徐懿喬,李春啟

廣東藥學院學報

2017

47

SOX5 predicts poor prognosis in lung adenocarcinoma and promotes tumor metastasis through epithelial-mesenchymal transition

Xin Chen, Yufei Fu, Hongfei Xu, Peng Teng, Qiong Xie, Yiran Zhang, Caochong
Yan, Yiqiao Xu, Chunqi Li, Jianying Zhou, Yiming Ni and Weidong Li

Oncotarget

2017

48

斑馬魚腫瘤異種移植模型在抗癌藥敏感性評價中的應用

勞喬聰,徐懿喬,金凡茂,陳嘉晟,湯敏佳,徐 雷,朱曉宇,鄭高利,宣堯仙,李春啟

中國比較醫學雜志

201711

49

桃紅四物湯對潑尼松誘導斑馬魚骨質疏松的治療作用

楊國柱 段濤 盧麗 陳珺 陸幸妍 李青南

中國骨質疏松雜志

20178

50

睡安片對咖啡因誘導斑馬魚失眠癥的改善作用

潘 蘭,黃 樂,葉志文,朱曉宇

現代藥物與臨床

20179

51

健脾益氣攝血方對辛伐他汀誘導斑馬魚出血模型的止血效果研究

褚雨霆,朱曉宇,張雅月,夏波,侯麗,

宋如順,李天天,李春啟,董青 ,陳信義

中國實驗血液學雜志

2017

52

安宮牛黃丸防治腦血管疾病作用研究

朱曉宇,郭勝亞,徐懿喬,楊華,李萍,

李春啟

藥物評價研究

20178

53

斑馬魚脾不統血證模型建立與健脾益氣攝血方止血療效研究

高寵,王佳,朱長樂,王沖,陳信義

中國科技論文在線

2017

54

Arachidonic Acid Induced
Thrombosis in Zebrafsh Larvae for Assessing Human AntiThrombotic Drugs

Yong Zhang,Sheng Ya Guo, Xiao Yu Zhu,Juan Zhou,
Wen han Liao, Gao Li Zheng, Ye Zuguang,and Chun Qi Li

JSM Cell & Developmental Biology

201711

55

健脾益氣攝血方及其拆方對辛伐他汀誘導斑馬魚肝出血防治作用研究

董青,朱長樂,陳信義,馬薇,張雅月,

田劭丹

中國科技論文在線

2018

56

Theabrownin triggers DNA damage to suppress human osteosarcoma U2OS cells by activating p53 signalling pathway.

Wangdong Jin,Li Zhou,Bo Yan,Li Yan,Fucun Liu,Peijian Tong,
Wenhua Yu, Xiaoqiao Dong, Li Xie, Jin Zhang, Yiqiao Xu,Chunqi Li,
Qiang Yuan, Letian Shan, Thomas Efferth

J Cell Mol Med

20187

57

黃地安消膠囊對高糖高脂誘導的斑馬魚血管病變保護作用研究

高家榮,郭明飛,方朝暉,姜輝,徐懿喬,

單樂天,魏良兵,單莉

中國中藥雜志

20186

58

Comparison of efcacy and toxicity of bevacizumab, endostar and apatinib in transgenic and human
lung cancer xenograftzebrafsh
model

Yinghua Jin, Lingxiao Wei, Qiuying Jiang, Xiaowei Song, Chong Teng, Chengjuan Fan,Yanju Lv, Ying Liu, Weixi Shen, Li Li, Dayong Huang & Tao Xin

Scientific Reports

201810

59

斑馬魚脾不統血證模型建立

高寵,王佳,王珺,朱曉宇,朱長樂,

郭勝亞,王沖,張佳諾,夏波,陳信義

世界中西醫結合雜志

20189

60

Design, synthesis and evaluation of novel ferulic acid derivatives as multi-target-directed ligands for the treatment of Alzheimers disease

Zhipei Sang, Keren Wang, Han Xue, Mengxiao Cao, Zhenghuai Tan, and Wenmin Liu

ACS CHEMICAL NEUROSCIENCE

201812

61

Evaluation of collagen mixture on promoting skin wound healing in zebrafish caused by acetic acid administration

Xiao-yun Xiong,Yi Liu,Le-tian Shan, Yi-qiao Xu, Jun Liang, Yu-Heng Lai,
Chung-Der Hsiao

Biochemical and Biophysical Research Communications

201810

62

Fenobucarb induces heart failure and cerebral hemorrhage in zebrafish

Xiao-Yu Zhu, Bo Xia, Yu-Ying Wu, Hua Yang, Chun-Qi Li, Ping Li

Aquatic Toxicology

201812

63

健脾益氣攝血方及其拆方對辛伐他汀誘導斑馬魚心臟出血模型血流量影響研究

田劭丹,朱長樂,石鳳芹,王沖,陳信義,

董青

中國科技論文在線

2019

64

二十五味珍珠片對斑馬魚微血管功能的影響

陳維武,白瑪卓瑪,郭勝亞,徐懿喬,

周生軍,陳倫舉

中國實驗方劑學雜志

20191


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